Description
Product Characteristics:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.
Subcellular location: Cell membrane
Synonyms: DHHC 7, DHHC7, FLJ10792, FLJ20279, Palmitoyltransferase ZDHHC7, ZDHHC 7, Zinc finger DHHC domain containing 7, Zinc finger DHHC domain containing protein 7, Zinc finger DHHC type containing 7, Zinc finger protein 370, ZNF 370, ZNF370,
Target Information: a zinc finger protein\, may have a role in sertoli cell differentiation [RGD, Feb 2006]